Triazoles Synthesis & Applications as Nonsteroidal Aromatase Inhibitors for Hormone-Dependent Breast Cancer Treatment

In the last few years, nonsteroidal aromatase inhibitors (AIs) have been emerged as promising agents for treating hormone-dependent breast cancer in postmenopausal women because of their inhibitory effect on estrogen synthesis. Indeed, these compounds can block activity aromatase, enzyme that intervenes steps production pathway. Triazoles are core structures AIs. The nitrogen atom triazole moiety plays a fundamental role functionality by interacting with iron ions heme group. general, AIs possess numerous advantages they quench step synthesis without any effects other steroids produced via same Some anastrozole, letrozole, and vorozole already approved Food Drug Administration treatment cancer. previously mentioned present severe adverse polycystic ovary syndrome (PCOS), resistance onset long-term treatments, higher risk bone fractures. This review focuses intensively hormone-sensitive types cancers, especially triazoles Also, provides an overview about chemistry along different methods which v -triazoles s-triazoles synthesized.